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18/07/27 Post-Doctoral Position : Extracellular Vesicles in Fungal-Plant Communication

Post-Doctoral Position : Extracellular Vesicles in Fungal-Plant Communication

Applications are invited for an ERA-CAPS-funded post-doctoral position at INRA-BIOGER, Thiverval-Grignon, France (https://www6.versailles-grignon.inr...). The position is for a period of 30 months and is available immediately.

Research project

The candidate will work within the framework of the ERA-CAPS project ‘Exosomes’, which involves collaboration with Prof. Roger Innes (Project Coordinator, Indiana University, USA), Prof. Blake Meyers (Danforth Plant Science Center, USA) and Prof. Hans Thordal-Christensen (University of Copenhagen, Denmark). Exosomes are small extracellular vesicles (EVs) secreted from cells by the fusion of multivesicular bodies (MVBs) with the plasma membrane. Although they are implicated in the intercellular transport of sRNAs and proteins in animals, little is known about EV functions in plants or fungi. The aim of the international consortium is to determine the role of EVs in plant-fungal interactions. At BIOGER, the Colletotrichum-Arabidopsis model pathosystem will be used to determine the cargoes of fungal EVs. Reverse genetics will be used to identify fungal genes involved in EV biogenesis and fluorescent tagged marker proteins will be used for live-cell imaging of EV and MVB dynamics. Plant-fungal interfaces formed at different stages of infection will be analysed by electron microscopy to study the ultrastructure of EV biogenesis and trafficking across cell walls. In parallel, fungal sRNAs produced during infection will be analysed and localized in situ by microscopy.

Profile

Applicants must have a PhD in fungal biology or plant-fungal interactions and should have published as first author in a top-ranking scientific journal. They should have strong expertise in molecular genetics and cell biology, including confocal and/or electron microscopy. Experience with plant-fungal interactions is desirable but not essential. Candidates must be able to work independently and have excellent communication skills. A good command of English is required for efficient interaction with our international partners. French language skills would be an advantage. Salary is on the INRA CR scale.

Applications

Candidates are requested to send a single PDF to Dr. Richard O’Connell (richard.oconnell chez inra.fr) containing : (a) a cover letter clearly explaining your motivation for applying for this project, (b) a description of your previous research experience, (c) a CV and publications list, and (d) email addresses of at least two referees. Applications will be considered until 31 August 2018.

Dr Richard O’Connell

Effectors of Fungal-Plant Communication Group

UMR1290 BIOGER

INRA-AgroParisTech

Avenue Lucien Brétignières

78850 Thiverval-Grignon, France

Email : richard.oconnell chez inra.fr

Telephone : +33 (0)1 30 81 45 82

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